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Article

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.

The EMBO journal - 1 Oct 1999

Dunckley T, Parker R

Abstract excerpt

The major pathway of mRNA degradation in yeast occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. To identify proteins that control the activity of the decapping enzyme, which is encoded by the DCP1 gene, we isolated a high-copy suppressor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10508173
DOI: 10.1093/emboj/18.19.5411
PMCID: PMC1171610

Genes

DCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10508173-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.PMID 10508173Read ↗

Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.Semantic proximity Read ↗

Analysis of mutations in the yeast mRNA decapping enzyme.Semantic proximity Read ↗

Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).Semantic proximity Read ↗

New insights into the control of mRNA decapping.Semantic proximity Read ↗

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functionsSemantic proximity Read ↗

A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster.Semantic proximity Read ↗

Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.Semantic proximity Read ↗

Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.Semantic proximity Read ↗

Crystal structure of Dcp1p and its functional implications in mRNA decapping.Semantic proximity Read ↗

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