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Article

HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein Secretion.

The Journal of biological chemistry - 4 Sept 2015

Zeitler Marcel, Steringer Julia P, Müller Hans-Michael, Mayer Matthias P, Nickel Walter

Abstract excerpt

HIV-Tat has been demonstrated to be secreted from cells in a phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent manner. Here we show that HIV-Tat forms membrane-inserted oligomers, a process that is accompanied by changes in secondary structure with a strong increase in antiparallel β sheet content. Intriguingly, oligomerization of HIV-Tat on membrane surfaces leads to the formation of membrane pores, as...

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Share to Fibroblast Growth Factor 2
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Spectroscopy, Fourier Transform Infrared

Share to tat Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 26183781
DOI: 10.1074/jbc.M115.667097
PMCID: PMC4571951

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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