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Article

Tetraspanin functions during HIV-1 and influenza virus replication

22 Mar 2011

Abstract excerpt

By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1 assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of...

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PMID: 21428933
DOI: 10.1042/bst0390529

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