Article
Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium.
Pflugers Archiv : European journal of physiology - 1 Aug 2015
Lee Jesun, Jung Jooyoung, Tak Min Ho, Wee Jungwon, Lee Byeongjoon, Jang Yongwoo, Chun Hyeyeon, Yang Dong-Jin, Yang Young Duk, Park Sang Ho, Han Byung Woo, Hyun Soonsil, Yu Jaehoon, Cho Hawon, Hartzell H Criss, Oh Uhtaek
Abstract excerpt
Anoctamin 1 (ANO1)/TMEM16A is a Cl(-) channel activated by intracellular Ca(2+) mediating numerous physiological functions. However, little is known of the ANO1 activation mechanism by Ca(2+). Here, we demonstrate that two helices, "reference" and "Ca(2+) sensor" helices in the third intracellular loop face each other with opposite charges. The two helices interact directly in a Ca(2+)-dependent manner....
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