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Article

Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.

The Journal of clinical investigation - 1 Oct 2012

Grier Jennifer T, Forbes Lisa R, Monaco-Shawver Linda, Oshinsky Jennifer, Atkinson T Prescott, Moody Curtis, Pandey Rahul, Campbell Kerry S, Orange Jordan S

Abstract excerpt

The Fc receptor on NK cells, FcγRIIIA (CD16), has been extensively studied for its role in mediating antibody-dependent cellular cytotoxicity (ADCC). A homozygous missense mutation in CD16 (encoding a L66H substitution) is associated with severe herpesvirus infections in rare patients. Here, we identified a new patient with this CD16 mutation and compared the patient's NK cells to those of the originally reported...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Epstein-Barr Virus Infections

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Source

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Identifiers

PMID: 23006327
DOI: 10.1172/JCI64837
PMCID: PMC3461929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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