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Article

Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection.

Journal of virology - 22 Dec 2020

Eschbach Jenna E, Elliott Jennifer L, Li Wen, Zadrozny Kaneil K, Davis Keanu, Mohammed Shawn J, Lawson Dana Q, Pornillos Owen, Engelman Alan N, Kutluay Sebla B

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein forms a conical lattice around the viral ribonucleoprotein complex (vRNP) consisting of a dimeric viral genome and associated proteins, together constituting the viral core. Upon entry into target cells, the viral core undergoes a process termed uncoating, during which CA molecules are shed from the lattice. Although the timing and degree of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33115869
DOI: 10.1128/JVI.00984-20
PMCID: PMC7944438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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