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Cryo Electron Tomography of Native HIV-1 Budding Sites

24 Nov 2010

Abstract excerpt

The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron microscopy, while no such studies have been reported for cellular HIV-1 budding sites. Here, we established a system for studying HIV-1 virus-like particle assembly and release by cryo electron tomography of intact human cells. The lattice of the structural Gag protein in budding sites was indistinguishable from that...

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PMID: 21124872
DOI: 10.1371/journal.ppat.1001173

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