Article
Biochemical and Structural Analysis of Isolated Mature Cores of Human Immunodeficiency Virus Type 1
1 Feb 2000
Abstract excerpt
Mature human immunodeficiency virus type 1 (HIV-1) particles contain a cone-shaped core structure consisting of the internal ribonucleoprotein complex encased in a proteinaceous shell derived from the viral capsid protein. Because of their very low stability after membrane removal, HIV-1 cores have not been purified in quantities sufficient for structural and biochemical analysis. Based on our in vitro assembly...
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