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Article

The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Lovero Kathryn L, Fukata Yuko, Granger Adam J, Fukata Masaki, Nicoll Roger A

Abstract excerpt

Synapse development is coordinated by a number of transmembrane and secreted proteins that come together to form synaptic organizing complexes. Whereas a variety of synaptogenic proteins have been characterized, much less is understood about the molecular networks that support the maintenance and functional maturation of nascent synapses. Here, we demonstrate that leucine-rich, glioma-inactivated protein 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26178195
DOI: 10.1073/pnas.1511910112
PMCID: PMC4522810

Genes

ADAM22
LGI1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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