Article
14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice.
Cell reports - 14 Dec 2021
Yokoi Norihiko, Fukata Yuko, Okatsu Kei, Yamagata Atsushi, Liu Yan, Sanbo Makoto, Miyazaki Yuri, Goto Teppei, Abe Manabu, Kassai Hidetoshi, Sakimura Kenji, Meijer Dies, Hirabayashi Masumi, Fukai Shuya, Fukata Masaki
Abstract excerpt
What percentage of the protein function is required to prevent disease symptoms is a fundamental question in genetic disorders. Decreased transsynaptic LGI1-ADAM22 protein complexes, because of their mutations or autoantibodies, cause epilepsy and amnesia. However, it remains unclear how LGI1-ADAM22 levels are regulated and how much LGI1-ADAM22 function is required. Here, by genetic and structural analysis, we...
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