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Article

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.

Molecular and cellular neurosciences - 1 Dec 2009

Owuor Katherine, Harel Noam Y, Englot Dario J, Hisama Fuki, Blumenfeld Hal, Strittmatter Stephen M

Abstract excerpt

Most epilepsy genes encode ion channels, but the LGI1 gene responsible for autosomal dominant partial epilepsy with auditory features produces a secreted protein. LGI1 is suggested to regulate PSD-95 via ADAM22. However, no unbiased screen of LGI1 action has been conducted. Here, we searched for...

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Source

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Identifiers

PMID: 19796686
DOI: 10.1016/j.mcn.2009.09.008
PMCID: PMC2783222

Genes

LGI1
ADAM23
ADAM22
ADAM11
PSD
ADAM12
CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19796686-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.PMID 19796686Read ↗

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Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA ReceptorsSemantic proximity Read ↗

Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy.Semantic proximity Read ↗

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.Semantic proximity Read ↗

Gene-Burden Meta-Analysis of 748,879 Individuals Identifies LGI1-ADAM23 Protein Complex Association with EpilepsySemantic proximity Read ↗

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