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Article

Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts.

PloS one - 1 Jan 2015

Carthy Jon M, Meredith Anna J, Boroomand Seti, Abraham Thomas, Luo Zongshu, Knight Darryl, McManus Bruce M

Abstract excerpt

BACKGROUND: Versican, a chondroitin sulphate proteoglycan, is one of the key components of the provisional extracellular matrix expressed after injury. The current study evaluated the hypothesis that a versican-rich matrix alters the phenotype of cultured fibroblasts. METHODS AND RESULTS: The full-length cDNA for the V1 isoform of human versican was cloned and the recombinant proteoglycan was expressed in murine...

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Identifiers

PMID: 26176948
DOI: 10.1371/journal.pone.0133056
PMCID: PMC4503433

Genes

SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts.PMID 26176948Read ↗

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Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.Semantic proximity Read ↗

Versican: signaling to transcriptional control pathwaysThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.Semantic proximity Read ↗

Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expressionSemantic proximity Read ↗

Versican Is Differentially Expressed in Human Melanoma and May Play a Role in Tumor DevelopmentSemantic proximity Read ↗

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V3 versican isoform expression alters the phenotype of melanoma cells and their tumorigenic potential.Semantic proximity Read ↗

Expression pattern and mapping of the murine versican gene (Cspg2) to chromosome 13.Semantic proximity Read ↗

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