Article
Versican and the regulation of cell phenotype in disease.
Biochimica et biophysica acta - 1 Aug 2014
Wight Thomas N, Kinsella Michael G, Evanko Stephen P, Potter-Perigo Susan, Merrilees Mervyn J
Abstract excerpt
BACKGROUND: Versican is an extracellular matrix (ECM) proteoglycan that is present in the pericellular environment of most tissues and increases in many different diseases. Versican interacts with cells to influence the ability of cells to proliferate, migrate, adhere and assemble an ECM. SCOPE OF REVIEW: The structure of the versican molecule is briefly reviewed and studies highlighting those factors that...
Topics
- Cells
- Disease
- Extracellular Matrix
- Humans
- Phenotype
- Proteolysis
- Versicans