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Article

Versican contributes to ligament formation of knee joints.

PloS one - 1 Jan 2021

Higuchi Tomoko, Suzuki Daisuke, Watanabe Takafumi, Fanhchaksai Kanda, Ota Keiko, Yokoo Kazuhisa, Furukawa Hiroshi, Watanabe Hideto

Abstract excerpt

Versican is a large proteoglycan in the extracellular matrix. During embryonic stages, it plays a crucial role in the development of cartilage, heart, and dermis. Previously, we reported that Prx1-Vcan conditional knockout mice, lacking Vcan expression in mesenchymal condensation areas of the limb bud, show the impaired joint formation and delayed cartilage development. Here, we investigated their phenotype in...

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Identifiers

PMID: 33886644
DOI: 10.1371/journal.pone.0250366
PMCID: PMC8061984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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