Article
V3 versican isoform expression alters the phenotype of melanoma cells and their tumorigenic potential.
International journal of cancer - 10 May 2005
Serra Montserrat, Miquel Laia, Domenzain Clelia, Docampo María José, Fabra Angels, Wight Thomas N, Bassols Anna
Abstract excerpt
Versican is a large chondroitin sulfate proteoglycan produced by several tumor cell types, including malignant melanoma. The expression of increased amounts of versican in the extracellular matrix may play a role in tumor cell growth, adhesion and migration. We have expressed the V3 isoform of versican in human and canine melanoma cell lines. Retroviral overexpression of V3 did not change the morphology of any of...
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