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Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression

28 Nov 2012

Abstract excerpt

Versican is a proteoglycan expressed in the extracellular matrix, where it regulates a variety of cell activities and affects tumor development. With alternative splicing, there are four versican isoforms, denoted V0, V1, V2 and V3. The V2 isoform is highly expressed in the mature brain but its function in the mature brain has not yet been elucidated. Since brain tumors are among the most angiogenic of human...

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PMID: 23201264
DOI: 10.1016/j.febslet.2012.11.023

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