Article
Versican proteolysis mediates myocardial regression during outflow tract development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2007
Kern Christine B, Norris Russell A, Thompson Robert P, Argraves W Scott, Fairey Sarah E, Reyes Leticia, Hoffman Stanley, Markwald Roger R, Mjaatvedt Corey H
Abstract excerpt
An important phase of cardiac outflow tract (OFT) formation is the remodeling of the distal region of the common outlet in which the myocardial sleeve is replaced by with smooth muscle. Here we demonstrate that expression of the proteoglycan versican is reduced before the loss of myocardium from the distal cardiac outlet concomitant with an increase in production of the N-terminal cleavage fragment of versican....
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