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Article

Versican A-subdomain is required for its adequate function in dermal development.

Connective tissue research - 1 Mar 2018

Hatano Sonoko, Nagai Naoko, Sugiura Nobuo, Tsuchimoto Jun, Isogai Zenzo, Kimata Koji, Ota Akinobu, Karnan Sivasundaram, Hosokawa Yoshitaka, Watanabe Hideto

Abstract excerpt

Versican, a large chondroitin sulfate (CS) proteoglycan, serves as a structural macromolecule of the extracellular matrix (ECM) and regulates cell behavior. We determined the function of versican in dermal development using VcanΔ3/Δ3 mutant mice expressing versican with deleted A-subdomain of the N-terminal G1 domain. The mutant versican showed a decreased hyaluronan (HA)-binding ability and failed to accumulate...

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Identifiers

PMID: 28488903
DOI: 10.1080/03008207.2017.1324432

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