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ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration

23 Apr 2018

Abstract excerpt

Liver has a unique regenerative capacity, however, its regulatory mechanism is not fully defined. We have established the zinc-finger protein ZBTB20 as a key transcriptional repressor for alpha-fetoprotein (AFP) gene in liver. As a marker of hepatic differentiation, AFP expression is closely associated with hepatocyte proliferation. Unexpectedly, here we showed that ZBTB20 acts as a positive regulator of hepatic...

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PMID: 29700307
DOI: 10.1038/s41419-018-0514-0

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