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Article

TGF-<b><i>β</i></b>Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the<b><i>α</i></b>-Fetoprotein Promoter

3 Jul 2014

Abstract excerpt

α-Fetoprotein (AFP) is known to be highly produced in fetal liver despite its barely detectable level in normal adult liver. On the other hand, hepatocellular carcinoma often shows high expression of AFP. Thus, AFP seems to be an oncogenic marker. In our present study, we investigated how TGF-β signaling cooperates with AT motif-binding factor-1 (ATBF1) to inhibit AFP transcription. Indeed, the expression of AFP...

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PMID: 25105025
DOI: 10.1155/2014/970346

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TGF-<b><i>β</i></b>Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the<b><i>α</i></b>-Fetoprotein PromoterPMID 25105025Read ↗

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