Article
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2021
Xie Bin, Khoyratty Tariq E, Abu-Shah Enas, F Cespedes Pablo, MacLean Andrew J, Pirgova Gabriela, Hu Zhiyuan, Ahmed Ahmed A, Dustin Michael L, Udalova Irina A, Arnon Tal I
Abstract excerpt
The PI3K pathway plays a key role in B cell activation and is important for the differentiation of Ab producing plasma cells (PCs). Although much is known about the molecular mechanisms that modulate PI3K signaling in B cells, the transcriptional regulation of PI3K expression is poorly understood. In this study, we identify the zinc finger protein Zbtb18 as a transcriptional repressor that directly binds...
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