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Article

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

13 Jul 2015

Abstract excerpt

Poor clinical outcome of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) has been attributed to failure of current chemotherapeutic regimens to target leukemic stem cells. We recently identified p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX), a gene functionally relevant for AML pathogenesis. In this study, we find that inhibition of PAK1 activity by...

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Identifiers

PMID: 26170031
DOI: 10.1182/blood-2014-12-618801

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