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Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells

13 Mar 2025

Abstract excerpt

BACKGROUND: The P21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a limited mechanistic understanding of their mode of action. Here, we aimed to characterize functional and molecular...

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PMID: 40082888
DOI: 10.1186/s12964-025-02107-0

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