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Article

WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia

20 Dec 2021

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strategies are required. Emerging evidence suggests that WTIP is a candidate tumor suppressor. However, the molecular mechanisms of WTIP in leukemogenesis have not been explored. Here, we report that WTIP expression is significantly reduced both in AML cell lines and clinical...

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Share to Acute Myeloid Leukemia Research
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PMID: 34930905
DOI: 10.1038/s41419-021-04467-0

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