Article
Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians.
PloS one - 1 Jan 2011
Vasan Senthil K, Neville Matt J, Antonisamy Belavendra, Samuel Prasanna, Fall Caroline H, Geethanjali Finney S, Thomas Nihal, Raghupathy Palany, Brismar Kerstin, Karpe Fredrik
Abstract excerpt
BACKGROUND: A feature of the Asian Indian phenotype is low birth weight with increased adult type 2 diabetes risk. Most populations show consistent associations between low birth weight and adult type 2 diabetes. Recently, two birth weight-lowering loci on chromosome 3 (near CCNL1 and ADCY5) were identified in a genome-wide association study, the latter of which is also a type 2 diabetes locus. We therefore...
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