Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2.

Oncogene - 24 Mar 2016

Yang E, Cisowski J, Nguyen N, O'Callaghan K, Xu J, Agarwal A, Kuliopulos A, Covic L

Abstract excerpt

As the majority of patients with basal-like breast carcinoma present with invasive, metastatic disease that do not respond to available therapies, it is essential to identify new therapeutic targets that impact invasion and metastasis. Protease-activated receptor 1 (PAR1), a G-protein coupled receptor has been shown to act as an oncogene, but underlying mechanisms are not well understood. Here, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to HMGA2 gene
Share to HMGA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MCF-7 Cells

Share to Neoplasm Metastasis

Share to Phenotype

Share to Receptor, PAR-1

Share to Vimentin

Source

Open in PubMed Open full text

Identifiers

PMID: 26165842
DOI: 10.1038/onc.2015.217
PMCID: PMC6818098

Genes

HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2.PMID 26165842Read ↗

Human Protease-Activated Receptor 1 Expression in Malignant EpitheliaSemantic proximity Read ↗

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patientsSemantic proximity Read ↗

Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer.Semantic proximity Read ↗

Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer CellsSemantic proximity Read ↗

Molecular heterogeneity in breast carcinoma cells with increased invasive capacities.Semantic proximity Read ↗

A Human Breast Cell Model of Preinvasive to Invasive TransitionSemantic proximity Read ↗

GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and SignalingSemantic proximity Read ↗

A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo.Semantic proximity Read ↗

Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer.Semantic proximity Read ↗

Masquerader: High Mobility Group Box-1 and CancerSemantic proximity Read ↗

Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion PlasticitySemantic proximity Read ↗

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.