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Article

A Human Breast Cell Model of Preinvasive to Invasive Transition

1 Mar 2008

Abstract excerpt

A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from preinvasive to invasive phenotype as it may occur "spontaneously" in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in...

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PMID: 18316601
DOI: 10.1158/0008-5472.can-07-2225

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