Article

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cells

2022-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Proteinase activated receptors (PARs) are G protein-coupled receptors (GPCRs) activated by limited N-terminal proteolysis. A variety of proteolytic enzymes derived from the coagulation cascade and inflammatory milieu activate PARs, however specific activators in different physiological and pathophysiological contexts remain poorly defined. PARs are highly expressed in many cancer cells and regul...

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Identifiers and source

Literature Corpus work: 49093700-4c58-5ca0-8454-b1b747b4538f
DOI: 10.1101/2022.08.22.504840

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