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Article

Human Protease-Activated Receptor 1 Expression in Malignant Epithelia

18 Mar 2003

Abstract excerpt

While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1...

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Share to Blood Coagulation and Thrombosis Mechanisms
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PMID: 12637343
DOI: 10.1161/01.atv.0000066878.27340.22

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