Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

doi:10.1158/1078-0432.CCR-18-0517

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2018

Méndez Olga, Peg Vicente, Salvans Cándida, Pujals Mireia, Fernández Yolanda, Abasolo Ibane, Pérez José, Matres Ana, Valeri Marta, Gregori Josep, Villarreal Laura, Schwartz Simó, Ramon Y Cajal Santiago, Tabernero Josep, Cortés Javier, Arribas Joaquín, Villanueva Josep

Abstract excerpt

PURPOSE: The study of the cancer secretome suggests that a fraction of the intracellular proteome could play unanticipated roles in the extracellular space during tumorigenesis. A project aimed at investigating the invasive secretome led us to study the alternative extracellular function of the nuclear protein high mobility group A1 (HMGA1) in breast cancer invasion and metastasis. EXPERIMENTAL DESIGN: Antibodies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Space

Share to Heterografts

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to Receptor for Advanced Glycation End Products

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed

Identifiers

PMID: 30135148
DOI: 10.1158/1078-0432.CCR-18-0517

Genes

HMGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer.PMID 30135148Read ↗

Exosomal lncRNA OIP5-AS1 confers cells trastuzumab resistance in breast cancer through miR-381-3p/HMGB3 axisSemantic proximity Read ↗

Overexpression of HMGB3 and its prognostic value in breast cancerSemantic proximity Read ↗

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patientsSemantic proximity Read ↗

Masquerader: High Mobility Group Box-1 and CancerSemantic proximity Read ↗

Multiple functions of HMGB1 in cancerSemantic proximity Read ↗

Epigenetic Alterations in Triple-Negative Breast Cancer—The Critical Role of Extracellular MatrixSemantic proximity Read ↗

Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENASemantic proximity Read ↗

Role of HMGB1 and its associated signaling pathways in human malignanciesSemantic proximity Read ↗

WNT10B/β‐catenin signalling induces HMGA2 and proliferation in metastatic triple‐negative breast cancerSemantic proximity Read ↗

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancerSemantic proximity Read ↗

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patientsSemantic proximity Read ↗

HMGA1 in cancer: Cancer classification by locationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.