Article
Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases.
Inflammatory bowel diseases - 1 Oct 2013
Gensollen Thomas, Bourges Christophe, Rihet Pascal, Rostan Agathe, Millet Virginie, Noguchi Tetsuro, Bourdon Violene, Sobol Hagay, Dubuquoy Laurent, Bertin Benjamin, Fumery Maturin, Desreumaux Pierre, Colombel Jean-Frédéric, Chamaillard Mathias, Hebuterne Xavier, Hofman Paul, Naquet Philippe, Galland Franck
Abstract excerpt
BACKGROUND: Vanin-1 is an epithelial pantetheinase, which regulates intestinal inflammation in mouse. We investigated whether human VNN1 levels could be associated to the susceptibility to inflammatory bowel diseases (IBD) and explored the participation of PPARg to these processes. METHODS: We st...
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