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Article

The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2015

Tao Ran, Chen Zekun, Wu Pingping, Liu Cuicui, Peng You, Zhao Weiwei, Hu Chaohui, Feng Jing

Abstract excerpt

Triple-negative breast cancer (TNBC) has a more invasive and metastatic potential than the other types of breast cancer and hence is associated with poor prognosis. Zeste homolog 2 (EZH2) and DNA methyltransferase 1 (DNMT1) could lead to tumorigenesis by separately methylating histone H3K27 and CpG islands in tumor suppressor genes. In order to investigate the association between oncogenesis and the distribution...

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Identifiers

PMID: 26162541
DOI: 10.1007/s13277-015-3754-y

Genes

DNMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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