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DNMT1 rs2228611, rs2228612 and DNMT3A rs2276598, rs752208 Polymorphisms and Their Association with Breast Cancer Phenotype and Prognosis.

Medicina (Kaunas, Lithuania) - 20 Nov 2024

Kaušylaitė Meda Marija, Jurevičė Justina, Korobeinikova Erika, Gudaitienė Jurgita, Juozaitytė Elona, Ugenskienė Rasa

Abstract excerpt

Background and Objectives: Breast cancer is a leading cause of cancer-related deaths globally. This study investigates the impact of genetic polymorphisms in DNA methyltransferases (DNMT1 and DNMT3A) on breast cancer pathomorphology and patient prognosis. Specifically, we focused on DNMT1 polymorphisms rs2228611 and rs2228612 and DNMT3A polymorphisms rs2276598 and rs752208. Materials and Methods: Conducted at the...

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Identifiers

PMID: 39597087
DOI: 10.3390/medicina60111902
PMCID: PMC11596321

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