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Article

Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among Chinese Han women in the Heilongjiang Province.

Clinical breast cancer - 1 Oct 2010

Xiang Gao, Zhenkun Fu, Shuang Chen, Jie Zhang, Hua Zhang, Wei Jiang, Da Pang, Dianjun Li

Abstract excerpt

BACKGROUND: Infiltrating ductal carcinoma (IDC) is the most common malignant breast cancer in women, and genetic factors appear to play a significant role in the susceptibility to IDC. Alteration of DNA methylation is an epigenetic change in human cancers, including breast cancer. DNA-methyltransferase 1 (DNMT1) is a major enzyme that determines genomic methylation patterns. In order to clarify the association of...

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Identifiers

PMID: 20920981
DOI: 10.3816/CBC.2010.n.049

Genes

DNMT1

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