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Article

Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology.

International journal of medical sciences - 1 Jan 2022

Liu Liang-Chih, Chien Yi-Chung, Wu Guo-Wei, Hua Chun-Hung, Tsai I-Chen, Hung Chih-Chiang, Wu Tsai-Kun, Pan Ying-Ru, Yang Shun-Fa, Yu Yung-Luen

Abstract excerpt

Triple-negative breast cancer (TNBC) is the third most common female cancer in Taiwan. EZH2 plays an important role in cancer development through transcriptional repression by chromatin remodeling. However, the expression of EZH2 in breast cancer is highly correlated with tumorigenesis, and patient survival is not matched to TNBC. Furthermore, it has not been determined if specific EZH2 genetic variants are...

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PMID: 35813302
DOI: 10.7150/ijms.71931
PMCID: PMC9254368

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