Article
Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer.
Oncotarget - 15 Sept 2015
Cheng Ningning, Cai Weijing, Ren Shengxiang, Li Xuefei, Wang Qi, Pan Hui, Zhao Mingchuan, Li Jiayu, Zhang Yishi, Zhao Chao, Chen Xiaoxia, Fei Ke, Zhou Caicun, Hirsch Fred R
Abstract excerpt
The aim of this study was to explore the role of long non-coding RNA UCA1 (urothelial cancer-associated 1) in acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). In our study, UCA1 expression was significantly increased in lung cancer cells and patients with acquired resistance to EGFR-TKIs. Over-expression of UCA1 was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.