Article
Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer.
Oncotarget - 2 Aug 2016
Pan Hui, Jiang Tao, Cheng Ningning, Wang Qi, Ren Shengxiang, Li Xuefei, Zhao Chao, Zhang Limin, Cai Weijing, Zhou Caicun
Abstract excerpt
Our previous study demonstrated that long non-coding RNA (lncRNA) BC087858 could stimulate acquired resistance to EGFR-TKIs in non-small cell lung (NSCLC) but the specific regulatory mechanism remained unknown. We aimed to explore the role and mechanism of lncRNA BC087858 on EGFR-TKIs acquired resistance. LncRNA BC087858 mRNA expression was detected by reverse transcription polymerase chain reaction in different...
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