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Article

Long Non-Coding RNA CRNDE Is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling.

International journal of molecular sciences - 13 Apr 2021

Takahashi Satoshi, Noro Rintaro, Seike Masahiro, Zeng Chao, Matsumoto Masaru, Yoshikawa Akiko, Nakamichi Shinji, Sugano Teppei, Hirao Mariko, Matsuda Kuniko, Hamada Michiaki, Gemma Akihiko

Abstract excerpt

(1) Background: Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is an intractable problem for many clinical oncologists. The mechanisms of resistance to EGFR-TKIs are complex. Long non-coding RNAs (lncRNAs) may play an important role in cancer development and metastasis. However, the biological process between lncRNAs and drug resistance to EGFR-mutated lung cancer...

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Identifiers

PMID: 33924522
DOI: 10.3390/ijms22084005
PMCID: PMC8070547

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Long Non-Coding RNA CRNDE Is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling.PMID 33924522Read ↗

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