Article
Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2015
Glendinning John I, Stano Sarah, Holter Marlena, Azenkot Tali, Goldman Olivia, Margolskee Robert F, Vasselli Joseph R, Sclafani Anthony
Abstract excerpt
Sensory stimulation from foods elicits cephalic phase responses, which facilitate digestion and nutrient assimilation. One such response, cephalic-phase insulin release (CPIR), enhances glucose tolerance. Little is known about the chemosensory mechanisms that activate CPIR. We studied the contribution of the sweet taste receptor (T1r2+T1r3) to sugar-induced CPIR in C57BL/6 (B6) and T1r3 knockout (KO) mice. First,...
Topics
- Administration, Oral
- Animals
- Behavior, Animal
- Blood Glucose
- Carbohydrates
- Chorda Tympani Nerve
- Food Preferences
- Fructose
- Genotype
- Glucose
- Glucose Tolerance Test
- Injections
- Insulin