Article

Cetuximab inhibits colorectal cancer development through inactivating the Wnt/β-catenin pathway and modulating PLCB3 expression

2023-08-24

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) often necessitates cetuximab (an EGFR-targeting monoclonal antibody) for treatment. Despite its clinical utility, the specific operative mechanism of cetuximab remains elusive. This research investigates the influence of PLCB3, a potential CRC oncogene, on cetuximab treatment. Methods We extracted differentially expressed genes (DEGs) from the GSE140...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed327d82-556f-59fa-a600-9495e2f5fa07
DOI: 10.21203/rs.3.rs-3258212/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cetuximab inhibits colorectal cancer development through inactivating the Wnt/β-catenin pathway and modulating PLCB3 expressionDOI 10.21203/rs.3.rs-3258212/v1Read

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathwaysSemantic proximity Read

Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.Semantic proximity Read

Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis.Semantic proximity Read

MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathwaySemantic proximity Read

Identification of molecular patterns of anoikis and epithelial-mesenchymal transition-combined index for colorectal cancer and the regulatory role of LTBP1 in colorectal cancerSemantic proximity Read

Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)Semantic proximity Read

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review).Semantic proximity Read

Identification of BGN and THBS2 as metastasis‐specific biomarkers and poor survival key regulators in human colon cancer by integrated analysisSemantic proximity Read

Wnt signaling in colorectal cancer: pathogenic role and therapeutic targetSemantic proximity Read

In silico analysis to identify miR-1271-5p/PLCB4 (phospholipase C Beta 4) axis mediated oxaliplatin resistance in metastatic colorectal cancerSemantic proximity Read

GABRP is a potential chemoresistance regulator in colorectal cancerSemantic proximity Read

Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancerSemantic proximity Read