Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer

7 Apr 2017

Abstract excerpt

Inflammation is frequently associated with initiation, progression, and metastasis of colorectal cancer (CRC). Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1. Using data from a large cohort of clinical samples including inflammatory bowel disease and CRC, and a cellular model of CRC progression mediated by cross-talk between the cancer cell and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood disorders and treatments
Share to Cancer Immunotherapy and Biomarkers
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28387757
DOI: 10.1038/cdd.2017.50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancerPMID 28387757Read ↗

<i>Growth Factor Independent 1</i> is a tumor suppressor gene in colorectal cancerSemantic proximity Read ↗

Growth Factor–Independent 1 Is a Tumor Suppressor Gene in Colorectal CancerSemantic proximity Read ↗

Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.Semantic proximity Read ↗

Colorectal cancer mouse models: Integrating inflammation and the stromaSemantic proximity Read ↗

Expression of FIBCD1 by intestinal epithelial cells alleviates inflammation-driven tumorigenesis in a mouse model of colorectal cancerSemantic proximity Read ↗

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtypeSemantic proximity Read ↗

Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1 <sup>+</sup> macrophage differentiationSemantic proximity Read ↗

A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1CSemantic proximity Read ↗

Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel TargetsSemantic proximity Read ↗

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.Semantic proximity Read ↗

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesisSemantic proximity Read ↗

Inflammation Amplifier, a New Paradigm in Cancer BiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.