Article
Targeted BRAF and CTNNB1 next-generation sequencing allows proper classification of nonadenomatous lesions of the sellar region in samples with limiting amounts of lesional cells.
Pituitary - 1 Dec 2015
Marucci Gianluca, de Biase Dario, Zoli Matteo, Faustini-Fustini Marco, Bacci Antonella, Pasquini Ernesto, Visani Michela, Mazzatenta Diego, Frank Giorgio, Tallini Giovanni
Abstract excerpt
PURPOSE: To assess the role of high sensitivity next-generation sequencing (NGS) of CTNNB1 for the diagnosis of adamantinomatous craniopharyngiomas (aCPs) and of BRAF for that of papillary CPs (pCPs) in routinely processed surgical samples of non-adenomatous sellar lesions. METHODS: Forty-five cases of patients operated for non-adenomatous masses of the sellar region between 2004 and 2014 were retrieved from the...
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