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Article

Prediction of CTNNB1 Mutation Status in Pediatric Cystic Adamantinomatous Craniopharyngioma by Using Preoperative Magnetic Resonance Imaging Manifestation.

Clinical neurology and neurosurgery - 1 Jan 2021

Zhu Wanchun, Tang Tianchi, Yuan Shijun, Chang Bowen, Li Shiting, Chen Ming

Abstract excerpt

OBJECTIVE: CTNNB1-targeted inhibitor is demonstrated to be an effective neoadjuvant therapy in adamantinomatous craniopharyngioma (ACP) patients and cystic degeneration is a canonical sign of pediatric ACP. This study aimed to investigate the relationship between the cystic performances and CTNNB1 mutation (CTNNB1 MUT) status so as to analyze the possible diagnostic criteria of CTNNB1 MUT in pediatric cystic ACP...

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PMID: 33160718
DOI: 10.1016/j.clineuro.2020.106347

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