BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma

Abstract excerpt

Craniopharyngiomas are epithelial, sellar tumours comprising two subtypes: adamantinomatous (aCP) and papillary (pCP). aCPs contain mutations in CTNNB1, encoding β-catenin: a component of the adherens junction and mediator of Wnt signalling. Reported frequency of CTNNB1 mutations varies widely (16–100 %) [6, 7]. Recently, it was reported that pCPs contain BRAF p.V600E mutations in 95 % of cases [2] and that...

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