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Article

Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.

Scientific reports - 9 Jul 2015

Carulla Patricia, Llorens Franc, Matamoros-Angles Andreu, Aguilar-Calvo Patricia, Espinosa Juan Carlos, Gavín Rosalina, Ferrer Isidre, Legname Giuseppe, Torres Juan Maria, del Río José A

Abstract excerpt

The cellular prion protein (PrP(C)) has been associated with a plethora of cellular functions ranging from cell cycle to neuroprotection. Mice lacking PrP(C) show an increased susceptibility to epileptic seizures; the protein, then, is neuroprotective. However, lack of experimental reproducibility has led to considering the possibility that other factors besides PrP(C) deletion, such as the genetic background of...

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Identifiers

PMID: 26155834
DOI: 10.1038/srep11971
PMCID: PMC4648388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.PMID 26155834Read ↗

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