Article
Deleterious c-Cbl Exon Skipping Contributes to Human Glioma.
Neoplasia (New York, N.Y.) - 1 Jun 2015
Seong Min Woo, Ka Seung Hyeun, Park Ji Ho, Park Jong Ho, Yoo Hee Min, Yang Seung Wook, Park Jung Mi, Park Dongeun, Lee Soon Tae, Seol Jae Hong, Chung Chin Ha
Abstract excerpt
c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor suppressor. Recently, we have shown that c-Cbl downregulates αPix-mediated cell migration and invasion, and the lack...
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