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Article

c-Cbl regulates αPix-mediated cell migration and invasion.

Biochemical and biophysical research communications - 12 Dec 2014

Seong Min Woo, Park Ji Ho, Yoo Hee Min, Yang Seung Wook, Oh Kyu Hee, Ka Seung Hyeun, Park Dong Eun, Lee Soon-Tae, Chung Chin Ha

Abstract excerpt

c-Cbl, a RING-type ubiquitin E3 ligase, down-regulates receptor tyrosine kinases, including EGF receptor, and inhibits cell proliferation. Moreover, c-Cbl mutations are frequently found in patients with myeloid neoplasm. Therefore, c-Cbl is known as a tumor suppressor. αPix is expressed only in highly proliferative and mobile cells, including immune cells, and up-regulated in certain invasive tumors, such as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-cbl

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Source

Identifiers

PMID: 25450678
DOI: 10.1016/j.bbrc.2014.10.129

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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