Article
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Nature communications - 7 Jul 2015
Tan Tien-Chye, Kracher Daniel, Gandini Rosaria, Sygmund Christoph, Kittl Roman, Haltrich Dietmar, Hällberg B Martin, Ludwig Roland, Divne Christina
Abstract excerpt
A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-binding cytochrome (CYT) connected via a flexible linker to a flavin-dependent dehydrogenase (DH)....
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