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Article

The role of the distal histidine in H2O2 activation and heme protection in both peroxidase and globin functions.

The journal of physical chemistry. B - 11 Oct 2012

Zhao Junjie, de Serrano Vesna, Dumarieh Rania, Thompson Matt, Ghiladi Reza A, Franzen Stefan

Abstract excerpt

The distal histidine mutations of dehaloperoxidase-hemoglobin A (DHP A) to aspartate (H55D) and asparagine (H55N) have been prepared to study the role played by the distal histidine in both activation and protection against oxidation by radicals in heme proteins. The H55D and H55N mutants of DHP A have ~6-fold and ~11-fold lower peroxidase activities than wild type enzyme toward the oxidation of...

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PMID: 22928870
DOI: 10.1021/jp300014b

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