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Article

Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.

Virology - 1 Feb 2003

Cooper Brooke, Schneider Steven, Bohl Joanna, Jiang Yong hui, Beaudet Arthur, Vande Pol Scott

Abstract excerpt

E6 oncoproteins from human papillomavirus type 16 (16E6) and Bovine Papillomavirus type 1 (BE6) bind to leucine rich peptides (called charged leucine, LXXLL, or signature peptides) found on target cellular proteins. BE6 and 16E6 both bind the product of the UBE3A gene called E6AP on a charged leucine peptide, LQELL. E6AP is an E3 ubiquitin ligase that together with 16E6 interacts with p53 to target p53...

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PMID: 12620801
DOI: 10.1016/s0042-6822(02)00012-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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